Taking DIM supplements might lower estrogen levels in postmenopausal women who use estrogen patches — one study found their urine had less estrogen when taking DIM.

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Pro

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Against

Evidence from Studies

Supporting (1)

49

Community contributions welcome

49

The impact of 3,3’-diindolylmethane on estradiol and estrogen metabolism in postmenopausal women using a transdermal estradiol patch

Cohort Study

Human

2025 Jul 1

The study found that taking DIM while using an estrogen patch changes how estrogen shows up in urine, which supports the idea that DIM might lower overall estrogen activity in the body.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

The impact of 3,3’-diindolylmethane on estradiol and estrogen metabolism in postmenopausal women using a transdermal estradiol patch

Score: 49

DOI: 10.1097/GME.0000000000002542

Similar Assertions

Taking DIM supplements might lower a certain estrogen byproduct in the urine of postmenopausal women who use estrogen patches — one study found levels were 22% lower in those taking DIM.

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92%

Postmenopausal women who use a supplement called DIM while on estrogen patches tend to have lower levels of a certain estrogen byproduct in their urine — about 23% lower — which might mean their bodies are processing the hormone differently.

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90%

Taking DIM supplements might help boost a certain healthy estrogen process in postmenopausal women who use estrogen patches — one study found their urine had 24% more of a specific marker linked to this process.

49

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86%

If postmenopausal women using estrogen patches also take a supplement called DIM, it might change how their body processes estrogen—lowering some types linked to higher risk and raising others that may be safer.

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0

79%