Women of Chinese Han descent who do strength training and have a specific gene version (AG) tend to lose more weight and shrink their waist and hips more than those with another gene version (AA).

A prospective, double-blind, randomized controlled trial enrolling Chinese Han women with confirmed rs731236 genotypes (AG vs. AA) who are assigned to identical, supervised resistance training programs (frequency: 3x/week, intensity: 70-80% 1RM, progression: weekly), with body weight, waist, and hip circumference measured at baseline, 8 weeks, and 16 weeks to compare changes between genotype groups.

A prospective cohort study following Chinese Han women who self-initiate resistance training, genotyped for rs731236 at baseline, with body composition (weight, waist, hip) tracked over 12–24 months using standardized protocols, comparing mean changes between AG and AA carriers while adjusting for age, baseline BMI, and training adherence.

A case-control study identifying Chinese Han women who completed at least 12 weeks of resistance training and achieved ≥5% reduction in body weight (cases) vs. those with <2% reduction (controls), matched for age, baseline BMI, and training frequency, then comparing rs731236 genotype distribution between groups.

A cross-sectional analysis of Chinese Han women currently undergoing resistance training, measuring current body weight, waist, and hip circumference and correlating these with rs731236 genotype status to determine if AG carriers have lower values than AA carriers.

An in vitro study using muscle cells derived from Chinese Han donors with known rs731236 genotypes (AG vs. AA), subjected to simulated mechanical stress (mimicking resistance training), measuring changes in gene expression, protein synthesis, and lipid metabolism pathways to assess genotype-dependent functional differences.