Women with systemic lupus erythematosus or systemic sclerosis produce more cortisol over the course of a day than women without these conditions, suggesting that their stress hormone system remains altered even when they are not under immediate stress.

36

Pro

0

Against

Evidence from Studies

Supporting (1)

36

Community contributions welcome

36

Does stress response axis activation differ between patients with autoimmune disease and healthy people?

Cross-Sectional Study

Human

2024 Aug

This study found that women with two autoimmune diseases, lupus and scleroderma, had more cortisol in their saliva throughout the day than healthy women, even without being stressed—meaning their body’s stress system is working differently all the time.

Contradicting (0)

0

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Does stress response axis activation differ between patients with autoimmune disease and healthy people?

Score: 36

DOI: 10.1002/smi.3392

Similar Assertions

Women with systemic lupus erythematosus and Sjögren's syndrome do not show an increase in salivary cortisol when exposed to psychological stress, while women without these conditions do. This suggests a difference in how the stress response system functions in these autoimmune diseases.

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Women with systemic sclerosis produce more cortisol over the course of a day than healthy women, even though their immediate cortisol response to stress is similar. This suggests a difference in overall cortisol regulation that is not tied to short-term stress reactions.

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Long-term stress can mess with your body's stress control system, making it harder to calm down and causing ongoing inflammation that might lead to health problems.

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