The Claim
Women diagnosed with systemic lupus erythematosus and systemic sclerosis exhibit higher total daily cortisol production compared to healthy women, indicating a persistent dysregulation of the hypothalamic-pituitary-adrenal axis that is independent of acute stress responses.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Women with systemic lupus erythematosus or systemic sclerosis produce more cortisol over the course of a day than women without these conditions, suggesting that their stress hormone system remains altered even when they are not under immediate stress.
See the scientific wording
Women with systemic lupus erythematosus and systemic sclerosis have higher total daily cortisol production than healthy women, suggesting a persistent dysregulation of the hypothalamic-pituitary-adrenal axis independent of acute stress responses.
What the research says
1 studyThis study found that women with two autoimmune diseases, lupus and scleroderma, had more cortisol in their saliva throughout the day than healthy women, even without being stressed—meaning their body’s stress system is working differently all the time.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.