Women with systemic lupus erythematosus and Sjögren's syndrome do not show an increase in salivary cortisol when exposed to psychological stress, while women without these conditions do. This suggests a difference in how the stress response system functions in these autoimmune diseases.

36

Pro

0

Against

Evidence from Studies

Supporting (1)

36

Community contributions welcome

36

Does stress response axis activation differ between patients with autoimmune disease and healthy people?

Cross-Sectional Study

Human

2024 Aug

When stressed, healthy women’s bodies release more cortisol, but women with lupus or Sjögren’s syndrome don’t—like their stress alarm system is broken. This study proves their bodies react differently to stress than healthy ones.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Does stress response axis activation differ between patients with autoimmune disease and healthy people?

Score: 36

DOI: 10.1002/smi.3392

Similar Assertions

Women with systemic lupus erythematosus or systemic sclerosis produce more cortisol over the course of a day than women without these conditions, suggesting that their stress hormone system remains altered even when they are not under immediate stress.

36

0

87%

Long-term stress can mess with your body's stress control system, making it harder to calm down and causing ongoing inflammation that might lead to health problems.

1

0

73%