The Claim

Women with systemic sclerosis exhibit higher total daily cortisol production (measured as AUCg) compared to healthy women, independent of similarities in acute stress response patterns during recovery.

Source: Does stress response axis activation differ between patients with autoimmune disease and healthy people?

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
36score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Description
1 study reviewed
In plain English

Women with systemic sclerosis produce more cortisol over the course of a day than healthy women, even though their immediate cortisol response to stress is similar. This suggests a difference in overall cortisol regulation that is not tied to short-term stress reactions.

See the scientific wording

Women with systemic sclerosis show higher total daily cortisol production (AUCg) than healthy women, despite a similar acute stress response pattern during recovery, indicating a dysregulation in overall cortisol output independent of acute stress reactivity.

What the research says

1 study

  1. Study: Does stress response axis activation differ between patients with autoimmune disease and healthy people?

    Women with systemic sclerosis make more cortisol throughout the day than healthy women, even though their bodies react the same way when they’re stressed — meaning their stress system is overactive all the time, not just during stressful moments.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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