Strong Support

When you exercise for a long time (over 2-3 hours), it's actually having low blood sugar that makes you feel tired and stop exercising—not your muscles running out of stored energy.

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Evidence from Studies

Supporting (1)

1

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This study reviewed over 160 studies and found strong evidence that low blood sugar (hypoglycemia) during exercise, not running out of muscle sugar (glycogen), is what really makes people stop exercising. When athletes take carbohydrates during exercise, it keeps blood sugar up and they can keep going even if their muscles are low on glycogen.

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.