Your body wastes more energy as heat when it turns fructose into fuel compared to glucose, because fructose needs extra steps and more energy just to get started.

When you eat fructose (like in soda), your body burns more calories digesting it than when you eat the same amount of sugar from glucose (like in bread), because your liver has to work harder to turn fructose into usable energy.

Eating fructose (like in sugary drinks) might be worse for your body than eating glucose (like in bread), because it can lead to more harmful fat buildup, insulin problems, and higher uric acid — all of which could increase your risk of heart disease.

When animals eat fructose, their liver breaks it down super fast without needing insulin, turning it mostly into glucose and lactate — and this might mess with the liver's energy and lead to health problems if it happens too much.