Scientists use tiny zebrafish with a condition similar to high insulin levels to study how insulin resistance works and how the immune system affects metabolic diseases, without needing obese animals.

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Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish.

Cross-Sectional Study

Animal

2014 Aug

The study tested whether zebrafish with high insulin levels (hyperinsulinemia) can be used to find new genes that control insulin resistance and to study immune-related metabolic diseases without obesity. The results confirmed that yes, this zebrafish model works well for both purposes.

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Source Study

Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish.

Score: 6

DOI: 10.1530/JOE-14-0178

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Scientists found that when they gave zebrafish babies a high amount of human insulin, the fish stopped responding to insulin properly - similar to what happens in humans with diabetes.

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When zebrafish babies are exposed to too much insulin for a long time, their immune system genes become less active - scientists proved this by looking at which genes are turned on or off.

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