Browse evidence-based analysis of health-related claims and assertions
When stressed, older mice's pancreatic cells have less MOTS-c than younger mice's cells.
Descriptive
MOTS-c helps pancreatic cells produce more energy through their mitochondria.
Correlational
Pancreatic cells from people with type 2 diabetes have less MOTS-c gene activity than healthy cells.
Adding more MOTS-c to pancreatic cells reduces genes involved in glutamine processing.
MOTS-c helps turn down genes linked to cell aging in pancreatic cells.
MOTS-c helps diabetic mice process sugar better and reduces aging signs in their pancreas cells.
Giving MOTS-c to diabetic mice helps reduce signs of aging in their pancreatic cells.
Older mice have less MOTS-c in their pancreatic cells than younger mice.
People with type 2 diabetes have less MOTS-c in their blood than people without diabetes.
Certain drugs like Metformin might help activate aging-related pathways, and some could work better with exercise, but this is just a theory from the abstract summary - full study details were not available
Working out your muscles might release helpful proteins, but this is just a theory from the abstract summary - full study details were not available
Having less body fat might help produce good hormones and reduce inflammation, but this is just a theory from the abstract summary - full study details were not available
When cells malfunction, it might cause problems like increased inflammation and aging processes, but this is just a theory from the abstract summary - full study details were not available
Mechanistic
Exercise or certain drugs might help cells work better and make it easier to exercise, but this is just a theory from the abstract summary - full study details were not available
Liver transplant patients with fatty liver disease who took saroglitazar saw a small increase in belly fat and fat under the skin. This finding is from the abstract summary - full study details were not available
Taking saroglitazar didn't make the muscles weaker or more fatty in liver transplant patients with fatty liver disease. This finding is from the abstract summary - full study details were not available
When liver transplant patients with fatty liver disease had lower levels of a liver enzyme called alkaline phosphatase after treatment, their liver fat also tended to decrease more. This finding is from the abstract summary - full study details were not available
About half of all patients and over 60% of those with higher initial liver fat saw their liver fat drop by at least 30% after taking saroglitazar for 24 weeks. This finding is from the abstract summary - full study details were not available
For people who had a liver transplant and have fatty liver disease, taking saroglitazar for 24 weeks lowered the amount of fat in their liver from about 10% to 8% on average. This finding is from the abstract summary - full study details were not available
When oxygen was low, MOTS-c treated diabetic rat hearts used less ATP, which may help protect the heart during low-oxygen events like heart attacks.
MOTS-c treatment made the diabetic rats' heart cells have more mitochondria, which are the energy factories of cells.
Diabetic rats given MOTS-c had lower blood sugar levels after fasting, showing better control of glucose.
Diabetic rats had weaker heart mitochondria energy production, but MOTS-c treatment helped improve it back to normal levels.
When diabetic rats were given MOTS-c daily for three weeks, their heart walls became slightly thinner, which is a sign of less heart enlargement.