Health Claims

Even though dapagliflozin lowered blood pressure, it didn't cause people with type 2 diabetes and healthy kidneys to excrete more salt in their urine when they ate a controlled amount of salt.

Taking dapagliflozin for two weeks lowered blood pressure by about 6-7 points in people with type 2 diabetes and healthy kidneys, even when they ate a controlled amount of salt.

Mice with kidney-specific PER1 removal have higher levels of a kidney signaling molecule called endothelin-1. This finding is from the abstract summary - full study details were not available

Removing PER1 from mouse kidneys changes how genes related to body clock and stress hormones work in the adrenal glands. This finding is from the abstract summary - full study details were not available

Mice with kidney-specific PER1 removal show higher levels of a hormone that regulates salt and blood pressure. This finding is from the abstract summary - full study details were not available

When mice have the PER1 protein removed from their kidneys, their daily salt excretion rhythm stays normal even with a high-salt diet and hormone treatment. This finding is from the abstract summary - full study details were not available

When mice have the PER1 protein removed specifically from their kidneys, they retain more salt when given a high-salt diet and a hormone treatment, which could affect blood pressure regulation. This finding is from the abstract summary - full study details were not available

Mice with extra kidney lymphatic vessels on a hypertension-inducing drug had lower blood pressure compared to normal mice.

Mice with extra kidney lymphatic vessels on a high-salt diet had lower levels of genes that control salt reabsorption in the kidneys.

When mice got a quick salt injection, extra kidney lymphatic vessels didn't change how much salt they excreted right away.

When mice ate a normal diet, growing more lymphatic vessels in their kidneys didn't change how they handled salt or water.

Mice with extra kidney lymphatic vessels had less of two key proteins that reabsorb salt in the kidneys, helping them excrete more salt.

Mice with extra kidney lymphatic vessels on a high-salt diet had more of a hormone that helps the body get rid of salt and water.

Mice with extra kidney lymphatic vessels on a hypertension-inducing drug excreted more sodium relative to their kidney function compared to normal mice.

Growing more lymphatic vessels in mouse kidneys during high-salt intake doubled the amount of fluid in the kidney tissue, acting like a sponge to hold extra fluid.

Mice with extra kidney lymphatic vessels on a high-salt diet excreted 64% more sodium in their urine compared to normal mice, helping them manage salt better.

When mice ate a high-salt diet, growing more lymphatic vessels in their kidneys lowered their blood sodium levels by about 4% compared to mice without extra lymphatic vessels.

Because this model includes detailed blood vessel and kidney cell features, it can simulate diseases and test drug effects.

Older kidney models only worked for one specific condition, but this new model works for many different situations and matches real rat data.

This kidney model is more detailed than other computer models of the whole body or kidney parts.

This is the first computer model to connect blood vessel and kidney tube functions in a single system.

A computer model of kidney function that includes how hormones affect kidney tubes and blood vessels can accurately simulate how the kidneys control salt and water levels in the body.

Mice missing the KDM6A gene in their kidneys show signs of faster aging, like higher levels of certain proteins linked to aging.

Giving Klotho to mice with high blood pressure caused by missing the KDM6A gene in kidneys lowers their blood pressure back to normal.