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Taking cholesterol drugs called evolocumab or alirocumab doesn’t seem to raise your risk of bleeding in the brain — the numbers show it’s about the same as not taking them.
Taking certain cholesterol drugs called evolocumab or alirocumab may help lower the chance of heart problems, whether you've already had heart issues or are just trying to prevent them.
Taking certain cholesterol drugs called evolocumab or alirocumab might lower the chance of having a stroke, whether you've already had heart problems or not.
Oral PCSK9 inhibitors can achieve approximately 58% reduction in LDL cholesterol, offering a non-injectable alternative to monoclonal antibody...
Ezetimibe reduces LDL cholesterol by inhibiting intestinal cholesterol absorption and is underutilized despite its efficacy, safety, and low cost.
Subclinical atherosclerosis develops in a linear relationship with LDL cholesterol levels, with plaque accumulation beginning at approximately 50–60...
Adding a drug called evolocumab to cholesterol-lowering statins can lower the chances of serious heart problems by 20% in people who already have heart disease.
Monoclonal antibody inhibition of PCSK9 with evolocumab reduces LDL cholesterol by approximately 81% in patients already on statin therapy.
PCSK9 promotes the degradation of hepatic LDL receptors, thereby reducing the liver's capacity to clear LDL cholesterol from the bloodstream.
Loss-of-function mutations in the PCSK9 gene are associated with lifelong lower LDL cholesterol and a substantially reduced risk of coronary heart...
Older men are more likely to use sarcastic or self-critical humour, while older women are more likely to use friendly and uplifting humour to cope with stress.
When older adults exercise together, it can help them feel less lonely — and part of why this works is because they use upbeat, friendly humor to connect with each other.
Older adults who exercise or play sports with friends tend to feel less lonely — and this is true both for those doing it now and those who did it in the past.
Sitting too much every day might make it harder for older Japanese adults to use humor in social situations, no matter what kind of humor they usually use.
Older adults who exercise or play sports with friends tend to use more positive, relationship-building humour and feel better mentally, according to a study of over 5,000 Japanese people aged 65 to...
Older people in China who feel their health is really poor are much more likely to show signs of depression. How you feel about your health might be a big clue about your mental well-being.
Older adults in both rural and urban China who have trouble with everyday tasks like dressing or managing bills are more likely to have depression, and this link is stronger in cities.
Older people living in rural parts of China are more likely to feel depressed than those in cities, even when you account for things like health problems or where they live in the country.
Older adults in China who have trouble with everyday tasks like handling money or taking their medicine are more likely to feel depressed, even when you account for other factors like where they live...
Older adults in China who have trouble with basic self-care tasks like bathing or dressing are nearly twice as likely to feel depressed compared to those who can do these tasks on their own.
In older Chinese adults, feeling depressed is linked to having more trouble with daily tasks — like cooking or dressing — and this link stays strong even when you account for things like age, health...
Older people in China are struggling more with depression, health problems, and daily tasks like cooking or dressing — and things have gotten worse over the past five years.
Feeling more down or depressed over time might make it harder for older adults in China to do everyday tasks like dressing or bathing — and having more trouble with those tasks might also make...
Feeling more down or depressed over time might make it harder for older adults in China to handle daily tasks like shopping or managing money — and struggling with those tasks might also make their...