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In obese male mice and non-human primates, blocking two specific proteins (GDF8 and activin A) while using a GLP-1 receptor agonist helps maintain or increase muscle mass and enhances fat loss,...
People with more fat around the abdomen compared to fat around the hips and thighs have a higher likelihood of developing polycystic ovary syndrome.
Increased levels of sex hormone-binding globulin, which is influenced by fat stored in the hips and thighs, reduce the amount of free testosterone in the body, and this mechanism accounts for about...
Higher levels of the hormone leptin explain about half of why fat stored around the hips and thighs is linked to a lower risk of polycystic ovary syndrome, as leptin influences how the body manages...
In individuals with polycystic ovary syndrome, a specific type of body fat around the hips and thighs appears to lower risk primarily by improving how the body responds to insulin, with fasting...
Women of European ancestry with a genetic tendency to store more fat around the hips and thighs have a 15.5% lower risk of developing polycystic ovary syndrome, likely due to better insulin...
In obese women aged 20–45, losing weight slowly or at a moderate pace lowers plasma interleukin-1 levels more than losing weight quickly, but none of these weight loss speeds significantly lower...
For obese women between 20 and 45 years old, losing weight through a low-calorie diet combined with aerobic and strength training reduces overall weight and waist size, but does not lead to different...
In obese women between 20 and 45 years old, losing weight quickly by cutting calories by 30–35% for 12 weeks does not lower levels of two inflammatory markers (IL-1 and hs-CRP) compared to their...
In obese women between 20 and 45 years old, losing weight at a moderate pace through a 20–25% calorie reduction over 10 weeks leads to a 22.66% decrease in plasma interleukin-1 levels compared to...
In obese women between 20 and 45 years old, losing weight slowly over 15 weeks with a moderate calorie reduction leads to a larger decrease in two markers of systemic inflammation—interleukin-1 and...
The strength with which fat cells bind to fat-burning signals is the same in belly and buttock fat, and the same in men and women. Differences in how easily fat is broken down are due to how many...
Fat breakdown in response to adrenaline varies between body regions only when adrenaline directly activates its receptor; when substances that act after the receptor are used, the variation...
In people who are not obese, fat cells around the abdomen break down fat more strongly in response to noradrenaline than fat cells in the buttocks, and this difference is larger in women than in men.
In women without obesity, fat cells around the abdomen are less responsive to signals that normally stop fat breakdown, compared to fat cells in the hips and thighs. This difference in signal...
In nonobese adults, fat cells in the abdomen have more beta-adrenoceptors than fat cells in the buttocks, and this correlates with a much stronger fat-breaking response to noradrenaline in abdominal...
In overweight adults, regular aerobic exercise does not lead to eating more food or increasing the calories burned from digestion. Instead, the body's overall energy balance changes mainly because it...
In overweight adults, doing aerobic exercise does not increase total daily calorie burn beyond what the exercise itself burns. Instead, the body adjusts by lowering the amount of energy used at rest,...
Overweight adults who engage in regular aerobic exercise use less oxygen when walking at a moderate pace, which reduces the amount of energy their body needs for everyday movement.
In overweight adults, regular aerobic exercise is linked to a small decrease in the size of the liver and kidneys, which might lower the body's resting energy use because these organs consume a lot...
When overweight adults walk for 12 weeks at a targeted energy expenditure level, their bodies burn fewer calories at rest and during sleep, reducing total energy expenditure by about 100 calories per...
When healthy adult males experience extreme calorie restriction at high altitudes, they lose about the same amount of body fat as they do muscle and other lean tissues.
When healthy adult men are in a state of severe calorie deficit at high altitude, consuming 2.0 grams of protein per kilogram of body weight per day leads to a higher rate of protein breakdown...
When healthy adult men at high altitude consume significantly fewer calories than they burn for three weeks, they lose about 3.6 kilograms of lean body mass, whether they eat 1.0 or 2.0 grams of...