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Noetel et al, BMJ 2024, "Effect of exercise for depression: systematic review and network meta-analysis of randomised controlled trials." 218 trials, 14,170 participants. Walking, strength training, and mixed aerobic all showed effect sizes comparable to SSRIs.
I did intermittent fasting in the past, & all I got was this lousy eating disorder & huge risk of death. A study of over 20,000 adults found that those who followed an 8-hour time-restricted eating schedule, a type of intermittent fasting, had a 91% higher risk of death from cardiovascular disease.
People really think that diet sodas prevent weight loss and cause metabolic problems. Quite the opposite! When substituting regular sodas for diet sodas people lose weight and get healthier. Yes they can also choose water but actually studies have found water and diet soda to be similar for weight loss with some edge towards the diet soda. Choose whichever you want!
Creatine may be one of the most misunderstood supplements. The science now reaches well beyond muscle growth, with research into healthy ageing, brain health, cognitive performance, bone health, and physical function. https://www.aukihenry.com/2026/06/the-new-case-for-creatine.html
Recent studies indicate that creatine, typically used for muscle growth, significantly benefits brain health. Research shows it crosses the blood-brain barrier to boost cognitive performance, aid depression treatment, and potentially slow Alzheimer’s decline by up to 30 percent.
Strength is not masculine. It is biological. If you are avoiding muscle because you think it changes your femininity, you are operating from the wrong framework. Your skeletal muscle regulates glucose disposal, supports insulin sensitivity, and protects long term function. Resistance training gives your body the signal to adapt. Protein gives your body the material to build. Choose strength. Like and subscribe for more science based health principles.
Can we finally agree that telling a PMOS patient to just lose weight is outdated medical advice? The weight gain is a direct symptom of metabolic dysfunction. We need doctors who understand endocrinology, not just scales.
More exciting results from a pilot study on creatine supplementation for Alzheimer’s disease. Participants who took 20 grams per day experienced a ~2 kg increase in handgrip strength and an increase in thigh muscle cross-sectional area after 8 weeks. That’s without training. These findings complement those of a prior publication showing higher brain creatine levels and improved cognition in the same participants. Definitely an area of research to keep an eye on!
Honest caveat: this is a mouse study. The mechanism is elegant, but no human trial has shown that a 15-PGDH inhibitor protects muscle in people on GLP-1s. Lifestyle is still the foundation: resistance training plus ~1.6 g/kg of protein remains the proven way to keep muscle on these drugs. (4/6)
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