Do high reps build sarcoplasmic hypertrophy and low reps build myofibrillar hypertrophy?

Rep Range & Hypertrophy1 min readUpdated June 2, 2026

What the Evidence Shows

We analyzed the available evidence on whether high reps build sarcoplasmic hypertrophy and low reps build myofibrillar hypertrophy. What we’ve found so far is that 39 studies or assertions support the idea that training with many repetitions leads to increases in the fluid and energy-storage parts...

Evidence from Studies

Supporting (0)
No supporting evidence found
Contradicting (0)
No contradicting evidence found
Primary Studies (1)

Muscle fiber hypertrophy in response to 6 weeks of high-volume resistance training in trained young men is largely attributed to sarcoplasmic hypertrophy

DOI: 10.1371/journal.pone.0215267

Update History

Published
June 2, 2026·Last updated June 2, 2026
  • Invalid DateNew topic created from assertion

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