Do radioactive iodine therapy and total thyroidectomy cause hypothyroidism requiring lifelong hormone replacement?

Thyroid Surgery & Hypothyroidism1 min readUpdated June 12, 2026

What the Evidence Shows

We analyzed the available evidence and found that 44 studies or assertions support the idea that patients treated with radioactive iodine therapy or total thyroidectomy develop hypothyroidism and need lifelong thyroid hormone medication. No studies or assertions in our review contradicted this. ...

Evidence from Studies

Supporting (0)
No supporting evidence found
Contradicting (0)
No contradicting evidence found
Primary Studies (1)

Quality of life in refractory Graves’ hyperthyroidism: a cross-sectional study comparing long-term ATDs therapy versus L-T4 replacement after iodine-131

DOI: 10.3389/fendo.2026.1776734

Update History

Published
June 12, 2026·Last updated June 12, 2026
  • Invalid DateNew topic created from assertion

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