Do sets performed near muscular failure stimulate both myofibrillar and sarcoplasmic hypertrophy?
What the Evidence Shows
We analyzed the available evidence and found that performing resistance exercises near muscular failure is associated with increases in both the contractile proteins and the fluid-filled components of muscle cells [1]. This suggests that training close to failure may stimulate changes in two key...
Evidence from Studies
Supporting (0)
No supporting evidence found
Contradicting (0)
No contradicting evidence found
Primary Studies (2)
Similar muscle hypertrophy following eight weeks of resistance training to momentary muscular failure or with repetitions-in-reserve in resistance-trained individuals
DOI: 10.1080/02640414.2024.2321021
Without Fail: Muscular Adaptations in Single Set Resistance Training Performed to Failure or with Repetitions-in-Reserve.
DOI: 10.1249/MSS.0000000000003728
Update History
Published
June 2, 2026·Last updated June 2, 2026- Invalid DateNew topic created from assertion