Do SGLT2 inhibitors increase endogenous glucose production and reduce glucose disposal in Zucker diabetic fatty rats?

SGLT2 Inhibitors & Glucose Metabolism1 min readUpdated May 31, 2026

What the Evidence Shows

We analyzed one assertion about SGLT2 inhibitors in Zucker diabetic fatty rats and found it supports the idea that these drugs increase endogenous glucose production and reduce glucose disposal. Specifically, in this strain of rats, a 7-day course of an SGLT2 inhibitor was linked to a roughly 30%...

Evidence from Studies

Supporting (0)
No supporting evidence found
Contradicting (0)
No contradicting evidence found
Primary Studies (1)

Correcting Postprandial Hyperglycemia in Zucker Diabetic Fatty Rats With an SGLT2 Inhibitor Restores Glucose Effectiveness in the Liver and Reduces Insulin Resistance in Skeletal Muscle

DOI: 10.2337/db16-1410

Update History

Published
May 31, 2026·Last updated May 31, 2026
  • Invalid DateNew topic created from assertion

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