Do SGLT2 inhibitors restore metabolic flexibility in Zucker diabetic fatty rats?

SGLT2 Inhibitors & Metabolic Flexibility1 min readUpdated May 31, 2026

What the Evidence Shows

We analyzed the available evidence on SGLT2 inhibitors and metabolic flexibility in Zucker diabetic fatty rats, and what we’ve found so far leans toward the idea that these drugs may help improve the body’s ability to switch between burning fat and glucose. In one study, a 7-day course of an SGLT2...

Evidence from Studies

Supporting (0)
No supporting evidence found
Contradicting (0)
No contradicting evidence found
Primary Studies (1)

Correcting Postprandial Hyperglycemia in Zucker Diabetic Fatty Rats With an SGLT2 Inhibitor Restores Glucose Effectiveness in the Liver and Reduces Insulin Resistance in Skeletal Muscle

DOI: 10.2337/db16-1410

Update History

Published
May 31, 2026·Last updated May 31, 2026
  • Invalid DateNew topic created from assertion

Sign up to see full analysis