Do sustained mechanical tension and accumulated fatigue from multiple sets increase muscle hypertrophy?
What the Evidence Shows
We analyzed the available research on whether sustained mechanical tension and accumulated fatigue from multiple sets increase muscle hypertrophy, and what we’ve found so far is mixed. Sixty studies suggest that performing multiple sets with prolonged tension and fatigue leads to greater muscle...
Evidence from Studies
Isotonic Resistance Exercise Outperforms Eccentric Quasi-Isometric Resistance Exercise for Increasing Elbow Flexor Muscle Thickness and Estimated One-Repetition Maximum in Untrained Individuals: Exploring the Influence of Sex and Volume.
DOI: 10.1139/apnm-2025-0039
Cross-bridge model-based quantification of muscle metabolite alterations leading to fatigue during all-out knee extension exercise
DOI: 10.3389/fphys.2026.1741796
Bench-Press Performed With a Velocity- and Tempo-Based Approach: Are There Differences in Volume Load, Time Under Tension, and Metabolic Demands?
DOI: 10.1177/19417381261416535
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