Does adding apitegromab to tirzepatide reduce loss of lean mass?

Muscle Preservation1 min readUpdated July 30, 2026

What the Evidence Shows

Based on the evidence we’ve reviewed so far, adding apitegromab to tirzepatide appears to reduce the loss of lean mass. Our analysis of available research leans toward this conclusion.

We examined one main assertion from the scientific literature: that taking both tirzepatide and apitegromab leads...

Evidence from Studies

Supporting (0)
No supporting evidence found
Contradicting (0)
No contradicting evidence found
Primary Studies (1)

Apitegromab for lean mass preservation during tirzepatide-induced weight loss: a randomized, double-blind, placebo-controlled phase 2 trial

DOI: 10.1038/s41591-026-04440-4

Update History

Published
July 30, 2026·Last updated July 30, 2026
  • Invalid Date1 new assertion(s) added

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