Does depression increase the link between loneliness and inflammation?

Depression & Inflammation1 min readUpdated May 29, 2026

What the Evidence Shows

We analyzed the available evidence and found that in older adults, loneliness appears to be more strongly linked to inflammation when depression symptoms are present or when there’s a genetic tendency toward depression. Specifically, we reviewed one assertion that showed the connection between...

Evidence from Studies

Supporting (0)
No supporting evidence found
Contradicting (0)
No contradicting evidence found
Primary Studies (1)

The reciprocal associations between social deficits, social engagement, and inflammation: Longitudinal evidence comparing venous blood samples and dried blood spots and mapping the modifying role of phenotypic and genotypic depression.

DOI: 10.1016/j.bbi.2024.03.045

Update History

Published
May 29, 2026·Last updated May 29, 2026
  • Invalid DateNew topic created from assertion

Sign up to see full analysis