Does physical exercise reduce systemic stress signaling and improve neuroendocrine regulation?
What the Evidence Shows
We analyzed the available evidence and found that 53 studies or assertions support the idea that physical exercise lowers markers of systemic stress and helps the neuroendocrine system function more effectively, with no studies contradicting this. The neuroendocrine system is the network that links...
Evidence from Studies
Supporting (0)
No supporting evidence found
Contradicting (0)
No contradicting evidence found
Primary Studies (3)
Concurrent inflammatory, hemorheological and macrovascular responses to a 230-km ultramarathon: an exploratory study
DOI: 10.1038/s41598-026-55821-1
Training Status Influences Regulation of Muscle and PBMC TLR4 Expression and Systemic Cytokine Responses to Vigorous Endurance Exercise
DOI: 10.1249/MSS.0000000000003618
Exercise as a multiscale recalibration of stress-related homeostatic balance
DOI: 10.3389/fnins.2026.1801865
Update History
Published
June 12, 2026·Last updated June 12, 2026- Invalid DateNew topic created from assertion