Does phytic acid activate HDAC3 and suppress MMP gene transcription in intestinal epithelial cells?

Phytic Acid & Gene Regulation1 min readUpdated June 8, 2026

What the Evidence Shows

We analyzed the available evidence and found one assertion suggesting that phytic acid, at a concentration of 10 nM, may bind to a specific protein domain to activate HDAC3, which in turn could lead to changes in histones that lower the activity of MMP genes in intestinal epithelial cells [1]. This...

Evidence from Studies

Supporting (0)
No supporting evidence found
Contradicting (0)
No contradicting evidence found
Primary Studies (1)

Phytic acid (InsP6) activates HDAC3 epigenetic axis to maintain intestinal barrier function

DOI: 10.1038/s41467-026-68994-0

Update History

Published
June 8, 2026·Last updated June 8, 2026
  • Invalid DateNew topic created from assertion

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