Is there a reciprocal relationship between CRP levels and loneliness in older adults?

CRP & Loneliness1 min readUpdated May 29, 2026

What the Evidence Shows

We analyzed the available evidence and found that in adults aged 65 and older, higher levels of C-reactive protein — a blood marker of inflammation — are linked to greater feelings of loneliness, and higher loneliness is also linked to later increases in this same marker [1]. This suggests a...

Evidence from Studies

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No supporting evidence found
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Primary Studies (1)

The reciprocal associations between social deficits, social engagement, and inflammation: Longitudinal evidence comparing venous blood samples and dried blood spots and mapping the modifying role of phenotypic and genotypic depression.

DOI: 10.1016/j.bbi.2024.03.045

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Published
May 29, 2026·Last updated May 29, 2026
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