Isolation exercises targeting a single joint (e.g., leg extensions) produce greater hypertrophy in bi-articular muscles (e.g., rectus femoris) compared to multi-joint compound movements (e.g., squats) due to avoidance of active insufficiency.

Isolation vs Compound Hypertrophy1 min readUpdated June 3, 2026

What the Evidence Shows

We analyzed the available evidence on whether isolation exercises like leg extensions lead to greater muscle growth in bi-articular muscles like the rectus femoris compared to compound movements like squats, specifically because isolation moves avoid active insufficiency. What we’ve found so far is...

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Published
June 3, 2026·Last updated June 3, 2026
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Isolation exercises targeting a single joint (e.g., leg extensions) produce greater hypertrophy in bi-articular muscles (e.g., rectus femoris) compared to multi-joint compound movements (e.g., squats) due to avoidance of active insufficiency. | Evidence-Based Answer | Fit Body Science