What do myokines like IL-6 and irisin do in the human body?
What the Evidence Shows
We analyzed the available evidence and found that muscle-released proteins like IL-6 and irisin are linked to changes in metabolism, immune response, and brain function in humans [1]. These proteins, called myokines, are produced by muscle tissue when it contracts during physical activity. IL-6,...
Evidence from Studies
Remodeling p38 signaling in muscle controls locomotor activity via IL-15
DOI: 10.1126/sciadv.adn5993
The impact of a single bout of high intensity circuit training on myokines' concentrations and cognitive functions in women of different age.
DOI: 10.1016/j.physbeh.2017.07.004
Suppressed brain-derived neurotrophic factor response to 6 min walking exercise in mild cognitive impairment
DOI: 10.1016/j.bbi.2026.106561
Impact of a single bout of high-intensity interval exercise and short-term interval training on interleukin-6, FNDC5, and METRNL mRNA expression in human skeletal muscle
DOI: 10.1016/j.jshs.2017.01.003
Update History
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