Research Database

Discovery of HYP-2A, a second-generation KRASG12C inhibitor designed to overcome resistance to existing drugs like Sotorasib and Adagrasib in KRASG12C-mutant...

To develop a pan-KRAS inhibitor (JAB-23E73) that targets multiple KRAS mutations, including those resistant to existing therapies.

This narrative review examines the evolution of direct RAS inhibitors, focusing on how previously 'undruggable' RAS mutations—especially KRASG12C—are now being...

The study aimed to identify previously unknown druggable pockets in oncogenic KRAS G12D using disulfide tethering, a site-directed fragment screening method,...

This study investigates why KRAS G12D and G12C oncogenic mutations differ in prevalence and function by analyzing their structural dynamics and effector...

This study investigates whether covalent inhibitors targeting both active and inactive states of KRAS G12C offer a therapeutic advantage over existing...

This study investigates whether a synthetic binding protein (monobody JAM20) can inhibit all RAS isoforms by targeting the Switch I/II pocket, a region...

Discovery of reversible small molecule inhibitors targeting multiple oncogenic Ras mutants by binding to a novel switch I-II pocket, aiming to overcome...

To evaluate sotorasib for treating advanced KRAS G12C-mutated non-small cell lung cancer (NSCLC) after prior systemic therapy.