Research Database

AFNT-111 is a TCR-engineered cellular therapy designed to target the KRASG12V mutation, a common driver in pancreatic, colorectal, and lung cancers, with the...

This study evaluates the safety and preliminary anti-tumor activity of FH-A11KRASG12V-TCR, an autologous T cell therapy targeting the KRAS G12V mutation in...

To develop and evaluate JAB-23425, a novel orally bioavailable inhibitor targeting multiple KRAS mutants (e.g., G12D, G12V, G13D) beyond the previously...

Discovery of HYP-2A, a second-generation KRASG12C inhibitor designed to overcome resistance to existing drugs like Sotorasib and Adagrasib in KRASG12C-mutant...

To develop a pan-KRAS inhibitor (JAB-23E73) that targets multiple KRAS mutations, including those resistant to existing therapies.

This narrative review examines the evolution of direct RAS inhibitors, focusing on how previously 'undruggable' RAS mutations—especially KRASG12C—are now being...

The study aimed to identify previously unknown druggable pockets in oncogenic KRAS G12D using disulfide tethering, a site-directed fragment screening method,...

This study investigates why KRAS G12D and G12C oncogenic mutations differ in prevalence and function by analyzing their structural dynamics and effector...

This study investigates whether covalent inhibitors targeting both active and inactive states of KRAS G12C offer a therapeutic advantage over existing...