What happens when monkeys eat too much fat?
Chronic high‐fat diet induces multi‐organ dysfunction and metabolic homeostasis disruption in Macaca fascicularis
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists fed monkeys a high-fat diet for 18 months to see if it would make them sick like humans who eat too much junk food.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 512 / 72
Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists fed monkeys a high-fat diet for 18 months to see if it would make them sick like humans who eat too much junk food.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 512 / 72
Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Publication
Authors
Chen H, Liu W, Zhou D, Liu S, Guan Y, Miao Z, Cai L, Li X, Li Y, Huang Z, Jin Y, Li G, Zhang Y
Related Content
Claims (6)
When animals are fed diets different from what they evolved to eat, they develop metabolic and cardiovascular diseases that do not occur in their natural wild environments.
In male macaque monkeys aged 10 to 15 years, feeding a high-fat diet for 18 months is linked to a 17.86% rate of diabetes, as defined by elevated blood glucose and HbA1c levels, along with changes in liver enzyme activity that indicate reduced glucose breakdown and increased glucose production.
In older male macaque monkeys fed a high-fat diet for 18 months, higher levels of a liver enzyme called BAAT in the blood are linked to less severe liver scarring, indicating that BAAT could potentially be used to track the progression of a liver disease similar to MASH.
In male macaque monkeys aged 10 to 15 years, feeding a high-fat diet for 18 months is linked to a high rate of liver damage characterized by fat accumulation, inflammation, cell swelling, and scarring, as well as a measurable increase in liver fat content via MRI.
In male macaque monkeys aged 10 to 15 years, feeding a high-fat diet for 18 months is linked to a 46.43% rate of heart muscle thickening, along with reduced activity of four specific genes involved in heart structure.