The Study
Melatonin as a Novel Drug to Improve Cardiac Function and Quality of Life in Heart Failure Patients: A Systematic Review and Meta‐Analysis
This study combines results from several small clinical trials to see if melatonin helps heart failure patients feel better. It shows that melatonin might help patients feel less tired and improve their daily life quality, but it doesn't clearly prove it makes the heart pump stronger. Because the studies were small and only done in one country, we can't be completely sure these results would happen everywhere.
Analysis score
Maximum 100 for a systematic review with meta-analysis.
Where the score came from
Researchers combined data from four studies to see if taking melatonin pills helps people with heart failure.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 539 / 100
Quality score
The highest quality evidence. Systematic reviews and meta-analyses that pool randomized controlled trials, giving the most reliable summary of experimental evidence.
Key takeaways
Summary
Based on the study abstract and findings.
- 1Yes, feeling better and having less heart stress is highly significant for daily life and long-term management, even if the heart's pumping number doesn't change.
- 2Melatonin significantly improved patients' quality of life and reduced fatigue and a heart stress marker, but did not significantly improve the heart's pumping strength.
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Clinical Cardiology
Year
2025
Authors
Abolfazl Sam Daliri, Nima Goudarzi, A. Harati, Kourosh Kabir
Related Content
Claims (5)
Taking melatonin pills might help heart failure patients who are losing weight and feeling exhausted by boosting their appetite, cutting down their tiredness, and improving their overall nutrition.
Taking melatonin by mouth might lower a specific stress marker in the blood for people with a common type of heart failure. This suggests the supplement could help take the strain off the heart and calm stress hormones, even if it doesn't change how well the heart pumps.
Taking melatonin supplements every day for a couple of months might help people with heart failure feel better physically and mentally. Studies show that compared to a fake pill, those who took melatonin reported noticeably better quality of life scores.
Taking melatonin pills for heart failure patients doesn't seem to help their hearts pump blood better. Research shows that adding melatonin to their treatment doesn't make a meaningful difference in how well their hearts work compared to just taking a placebo.
Taking melatonin supplements helps improve blood vessel health in heart failure patients who don't have diabetes, but it doesn't seem to help those who do have diabetes. This suggests that a person's blood sugar levels might change how well melatonin works to protect the heart and blood vessels.
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.