Hormones Make Prostate Cancer Grow and Spread in Mice
Steroid hormones stimulate human prostate cancer progression and metastasis
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists gave some mice extra hormones and saw their prostate cells turn into cancer that spread, while mice without extra hormones stayed healthy.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
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A snapshot of a population at a single point in time. Can identify correlations and prevalence, but cannot determine the direction of cause and effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists gave some mice extra hormones and saw their prostate cells turn into cancer that spread, while mice without extra hormones stayed healthy.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 511 / 44
Evidence Score
A snapshot of a population at a single point in time. Can identify correlations and prevalence, but cannot determine the direction of cause and effect.
Publication
Authors
Ricke WA, Ishii K, Ricke EA, Simko J, Wang Y, Hayward SW, Cunha GR
Related Content
Claims (6)
When scientists gave mice special hormone treatments, the tissue samples from those mice grew bigger and heavier compared to tissue from mice that didn't get the treatment. This shows hormones can make tissues grow more.
When mice were given certain hormone implants, they got cancerous tumors with messy tissue, but mice without the treatment kept healthy, organized tissue.
When scientists gave hormone implants to special lab mice with human prostate cells, the mice's hormone levels went way up compared to mice that didn't get the treatment.
In a study with mice, giving them certain hormones caused cancer cells to spread to other parts of the body like the lungs and liver, but mice that didn't get the hormones didn't have this spread.
Cells from mice given hormones grew into big, spreading cancers even without extra help when moved to other mice, but cells from mice not given hormones stayed harmless and didn't cause cancer.