Why some people's bodies stop fat-burning better when insulin rises
Upstream transcription factor 1 gene polymorphisms are associated with high antilipolytic insulin sensitivity and show gene–gene interactions
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Some people have special gene versions that make their fat cells respond more strongly to insulin — meaning insulin shuts down fat release better in them.
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Evidence Score
A snapshot of a population at a single point in time. Can identify correlations and prevalence, but cannot determine the direction of cause and effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Some people have special gene versions that make their fat cells respond more strongly to insulin — meaning insulin shuts down fat release better in them.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 533 / 44
Evidence Score
A snapshot of a population at a single point in time. Can identify correlations and prevalence, but cannot determine the direction of cause and effect.
Publication
Authors
Kantartzis K, Fritsche A, Machicao F, Stumvoll M, Machann J, Schick F, Häring HU, Stefan N
Related Content
Claims (6)
When insulin levels rise, it reduces the breakdown of fat in fat cells by suppressing the enzyme hormone-sensitive lipase.
Certain variations in the USF1 gene are linked to a larger decrease in free fatty acids in the blood during a glucose tolerance test in Caucasian adults, suggesting these genetic differences affect how insulin controls fat breakdown in fat tissue.
People with two specific genetic variants in the USF1 gene show a stronger reduction in fat release from fat cells when insulin is present, and their bodies respond more effectively to insulin in metabolic tests, suggesting these variants are linked to better fat regulation under insulin control.
People with specific combinations of genetic variants in the USF1 and LIPC genes have been observed to have higher levels of fat in their liver, as measured by a specialized imaging technique, which may indicate a higher likelihood of developing fatty liver disease.
Genetic variations in the USF1 gene affect how insulin suppresses fat breakdown, but this effect does not change based on whether a person also has a specific variation in the HSL gene.