Why inflamed blood vessels get clogged first
Chronological in vivo imaging reveals endothelial inflammation prior to neutrophils accumulation and lipid deposition in HCD-fed zebrafish.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
In fish with high cholesterol, the inside of their blood vessels gets inflamed before fat builds up or white blood cells show up. Giving them a special medicine calms the inflammation and reduces the fat buildup.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 58 / 72
Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
In fish with high cholesterol, the inside of their blood vessels gets inflamed before fat builds up or white blood cells show up. Giving them a special medicine calms the inflammation and reduces the fat buildup.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 58 / 72
Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Publication
Authors
Luo H, Li QQ, Wu N, Shen YG, Liao WT, Yang Y, Dong E, Zhang GM, Liu BR, Yue XZ, Tang XQ, Yang HS
Related Content
Claims (4)
The buildup of fats and plaques in artery walls requires prior inflammation of the inner lining of blood vessels.
In zebrafish with high cholesterol, changes in specific inflammatory molecules in blood vessel lining occur before immune cells and fat build up in the vessels, suggesting a sequence of early events leading to artery damage.
In zebrafish with high cholesterol, the drug rosiglitazone reduces levels of certain inflammatory molecules in blood vessel cells and decreases the buildup of immune cells and fat deposits.
In zebrafish with high cholesterol, inflammation in blood vessel lining involves reduced levels of PPARγ and elevated levels of TNF-α and IL-1β, which together form a detectable molecular pattern of early vascular inflammation.