How a vitamin-like substance helps yeast live longer
Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Nicotinamide riboside extended lifespan in yeast, despite previous reports that NAD+ precursors accelerated aging.
Earlier studies suggested NAD+ precursors might shorten lifespan, so finding that one (nicotinamide riboside) actually extends it contradicts prior expectations.
Practical Takeaways
Consider supplements that support NAD+ production, like nicotinamide riboside, as potential longevity aids — but with caution.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Nicotinamide riboside extended lifespan in yeast, despite previous reports that NAD+ precursors accelerated aging.
Earlier studies suggested NAD+ precursors might shorten lifespan, so finding that one (nicotinamide riboside) actually extends it contradicts prior expectations.
Practical Takeaways
Consider supplements that support NAD+ production, like nicotinamide riboside, as potential longevity aids — but with caution.
Publication
Journal
Cell
Year
2007
Authors
Peter Belenky, Frances G. Racette, Katrina L. Bogan, Julie M. McClure, Jeffrey S. Smith, Charles Brenner
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Claims (3)
Giving yeast a special vitamin-like compound helps keep their DNA more stable and better controlled by boosting a key molecule in their cells.
A supplement called nicotinamide riboside helps yeast cells live longer by boosting a key molecule in their cells and turning on a longevity gene, even without cutting calories.
In yeast, nicotinamide riboside helps extend life and turn off certain genes, but only if it boosts NAD+ levels using two specific recycling systems in the cell.