NMN helps old mice stay healthier as they age
Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
NMN prevented over 76% of age-related gene changes in muscle — not just symptoms, but the underlying genetic shifts.
Most anti-aging claims focus on appearance or function, but reversing or preventing gene expression drift is far more profound and rare in intervention studies.
Practical Takeaways
Consider NAD+ support through diet (e.g., milk, fish) or early-stage supplements like NMN or NR while research evolves.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
NMN prevented over 76% of age-related gene changes in muscle — not just symptoms, but the underlying genetic shifts.
Most anti-aging claims focus on appearance or function, but reversing or preventing gene expression drift is far more profound and rare in intervention studies.
Practical Takeaways
Consider NAD+ support through diet (e.g., milk, fish) or early-stage supplements like NMN or NR while research evolves.
Publication
Journal
Cell metabolism
Year
2016
Authors
K. Mills, Shohei Yoshida, L. Stein, Alessia Grozio, Shunsuke Kubota, Y. Sasaki, P. Redpath, M. Migaud, R. Apte, K. Uchida, J. Yoshino, S. Imai
Related Content
Claims (5)
Giving male mice a supplement called NMN every day for a year helped them gain less weight as they aged — the higher the dose, the less weight they gained — and didn’t seem to cause any harm.
In older male mice, taking a supplement called NMN every day for a year helped their bodies respond better to insulin — a hormone that controls blood sugar — even if their weight didn’t change.
Giving older male mice a supplement called NMN every day for six months might help their muscles produce energy better by boosting the health of their cellular powerhouses.
Giving male mice a supplement called NMN every day for a year seems to help their eyes work better as they get older, especially in a type of mouse prone to eye problems.
Giving male mice a supplement called NMN for a year seems to help keep their muscle, fat, and liver genes from changing as they age — especially in muscle and fat, where most age-related gene shifts didn’t happen.