The Study
Clinical efficacy of nitric oxide nasal spray (NONS) for the treatment of mild COVID-19 infection
This study is like a fair test comparing two groups. It shows the nasal spray probably helps reduce the virus amount in people with mild COVID-19, but we don't know if it actually helps people feel better faster or stop spreading the virus.
Analysis score
Maximum 90 for a randomized controlled trial.
Where the score came from
A nose spray with nitric oxide helped people with mild COVID-19 get better quicker by reducing the virus in their nose and throat.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 568 / 100
Quality score
Participants are randomly assigned to treatment or control groups, minimizing bias. The gold standard for testing whether an intervention causes an effect.
Key takeaways
Summary
Based on the study abstract and findings.
- 1Yes, it shows the spray can quickly lower virus levels and help people recover faster from mild COVID-19.
- 2Virus reduced 16 times faster by day 4; 95% gone in 1 day, 99% in 3 days; almost half felt better in 2-4 days vs.
- 38% with placebo.
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Journal of Infection
Year
2021
Authors
Stephen Winchester, Sarah John, Kashif Jabbar, Isaac John
Related Content
Claims (5)
A nose spray with nitric oxide was tested on adults who had mild COVID-19. The study found that no one had any serious side effects from using the spray for 9 days.
A nose spray with nitric oxide helps people with mild COVID-19 get rid of the virus faster. When used several times a day for over a week, it reduces the virus amount 16 times quicker than a placebo spray by the second and fourth days.
A nose spray with nitric oxide might quickly lower the amount of COVID-19 virus in your body, cutting it by 95% in one day and 99% in three days for people with mild symptoms.
A nose spray with nitric oxide helps people with mild COVID-19 feel better faster. Almost half of users felt improved within a few days, while only a few did with a fake spray.
A nasal spray with nitric oxide helps people with mild COVID-19 by reducing the amount of virus in their body over a week of treatment, making them less sick.
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.