Stress makes autoimmune diseases worse — but diet and exercise can help

Original Title

Allostatic load elevates the risk and adverse prognosis of immune-mediated inflammatory diseases: modulatory effects of lifestyle interventions and genetic susceptibility

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Summary

When your body is under long-term stress, it wears down your immune system and makes diseases like type 1 diabetes and arthritis more likely — but eating omega-3s and moving more can partly fix that.

Proposed Mechanism
Chronic Stress-Induced Immune Dysregulation via HPA and Sympathetic Activation
Suggested
ω-3 PUFA Attenuation of Stress-Induced Inflammation
Suggested
Physical Activity Mitigation of Stress-Induced Immune Activation
Suggested
Genetic Susceptibility Amplification of Stress-Induced Immune Dysregulation
Suggested

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Quality Analysis
Methodology
59%
Moderate QualityOverall Score
Cohort StudyMedicine

Systematic Reviews & Meta-Analyses

Max 100

Randomized Controlled Trials

Max 90

Cohort Studies

Max 72

Case-Control Studies

Max 58

Cross-Sectional Studies

Max 44

Case Reports & Case Series

Max 30

Expert Opinion & Narrative Reviews

Max 5
StrongerWeaker
Cohort Studies
Level 2
59

59 / 72

Evidence Score

Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.

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