The Study
Daytime restricted feeding Promotes Circadian Desynchrony and Metabolic Disruption with Changes in Bile Acids profiles and Gut Microbiota in C57BL/6 Male Mice.
This study showed that when mice eat during their sleep time, their body clocks get confused and their gut bacteria and liver chemicals change. But this only happened in mice, not people, so we can't say the same thing will happen to humans.
Analysis score
Maximum 90 for a randomized controlled trial.
Where the score came from
Mice that ate only during the day (when they normally sleep) had their body clocks and gut bacteria thrown out of sync.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 513 / 100
Quality score
Participants are randomly assigned to treatment or control groups, minimizing bias. The gold standard for testing whether an intervention causes an effect.
Key takeaways
Summary
Based on the study abstract and findings.
- 1This suggests that eating at the wrong time may disrupt how the body manages energy and digestion, even if the total food intake doesn't change.
- 2Daytime eating changed the daily rhythm of liver genes, made bile acids higher in the morning and lower at night, and increased 'bad' gut bacteria while decreasing 'good' ones.
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
The Journal of nutritional biochemistry
Year
2022
Authors
Yuan Cui, Shilan Li, Yan Yin, Xinran Li, Xinli Li
Related Content
Claims (5)
Gut microbes follow a daily rhythm, and prolonged periods without food are necessary for them to carry out repair processes in the lining of the intestine.
In male C57BL/6 mice, feeding only during daytime changes the gut microbiome by increasing Firmicutes and the Firmicutes-to-Bacteroidetes ratio, reducing Verrucomicrobia, and altering the daily rhythm of Akkermansia, Lactobacillus, and Parabacteroides bacteria.
In male C57BL/6 mice, feeding only during daytime alters the daily timing of liver gene activity involved in fat processing and bile acid production, causing a mismatch between the body's internal clock and metabolic functions.
In male C57BL/6 mice, feeding only during the day causes higher levels of certain bile acids in feces at midday and lower levels at midnight, altering the natural daily rhythm of these compounds.
In male C57BL/6 mice, feeding during the normal rest period disrupts the timing of liver circadian rhythms and metabolic functions, and alters the daily patterns of bile acids and gut bacteria in the feces.
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.