Why do we need new weight loss medicines if we already have good ones?
Why are we still in need for novel anti-obesity medications?
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
We have powerful new medicines that can help people lose a lot of weight, but many stop taking them because they feel sick or don’t get enough support. Some also lose muscle, and weight comes back when they stop. Scientists are working on even better medicines that might fix these problems.
Surprising Findings
Real-world dropout rates are up to 50%, despite clinical trials showing high tolerability.
Clinical trials report very low discontinuation due to side effects, but real-world data shows most patients quit—revealing a major gap between controlled studies and everyday life.
Practical Takeaways
If you're starting a GLP-1 drug, ask your doctor about a slower, flexible dose escalation to improve tolerance.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
We have powerful new medicines that can help people lose a lot of weight, but many stop taking them because they feel sick or don’t get enough support. Some also lose muscle, and weight comes back when they stop. Scientists are working on even better medicines that might fix these problems.
Surprising Findings
Real-world dropout rates are up to 50%, despite clinical trials showing high tolerability.
Clinical trials report very low discontinuation due to side effects, but real-world data shows most patients quit—revealing a major gap between controlled studies and everyday life.
Practical Takeaways
If you're starting a GLP-1 drug, ask your doctor about a slower, flexible dose escalation to improve tolerance.
Publication
Journal
The Lancet Regional Health - Europe
Year
2024
Authors
Aaron Novikoff, Gerald Grandl, Xue Liu, T. Müller
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Claims (3)
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