The Study
Dietary advanced glycation end-products and postmenopausal hot flashes: A post-hoc analysis of a 12-week randomized clinical trial.
This study found that when women ate a very specific plant-based diet, their hot flashes got better — but it doesn't prove that eating less AGEs alone caused the improvement, because the whole diet changed. It's like noticing your headache went away after you started drinking more water and sleeping earlier — you can't be sure which one helped.
Analysis score
Maximum 90 for a randomized controlled trial.
Where the score came from
Scientists gave some women a special plant-based diet with soybeans to see if it helped with hot flashes.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 568 / 100
Quality score
Participants are randomly assigned to treatment or control groups, minimizing bias. The gold standard for testing whether an intervention causes an effect.
Key takeaways
Summary
Based on the study abstract and findings.
- 1Yes — cutting AGEs by about 7000 units per day was linked to one fewer severe hot flash every day, which could make a big difference in daily comfort.
- 2Women who ate soy and followed a low-fat vegan diet had 92% fewer severe hot flashes and 88% fewer moderate-to-severe hot flashes.
- 3Their dietary AGEs dropped by 73%.
- 4The more AGEs went down, the more hot flashes decreased.
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Maturitas
Year
2023
Authors
H. Kahleová, Tatiana Znayenko-Miller, J. Uribarri, Natalie Schmidt, Sinjana Kolipaka, Ellen Hata, D. Holtz, Macy Sutton, R. Holubkov, N. Barnard
Related Content
Claims (6)
Postmenopausal women who ate 86 grams of cooked whole soybeans daily as part of a low-fat plant-based diet experienced an 88% reduction in moderate-to-severe hot flashes, while those who did not had a 34% reduction.
Postmenopausal women who eat 86 grams of cooked whole soybeans daily as part of a low-fat plant-based diet experience a 79% reduction in total hot flashes and an 84% reduction in moderate-to-severe hot flashes after 12 weeks.
Among postmenopausal women, a diet that includes whole soybeans and is low in fat led to 59% of participants no longer experiencing moderate-to-severe hot flashes after 12 weeks.
Postmenopausal women who consume 6933 ku/day fewer dietary advanced glycation end-products experience one fewer severe hot flash per day.
Postmenopausal women who ate a low-fat vegan diet with 86 grams of cooked soybeans daily for 12 weeks experienced a 73% reduction in dietary advanced glycation end-products and a 92% reduction in the frequency of severe hot flashes.
In postmenopausal women, lower intake of dietary advanced glycation end-products was associated with fewer severe and moderate-to-severe hot flashes, after accounting for changes in calorie intake and body weight.
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.