How a pile of blood vessel cells turns into fatty gunk
Stacked human aortic endothelial cells induce atherosclerotic fatty streaks and release proinflammatory cytokines and chemokines
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists stacked up blood vessel cells in a dish and found they turned into weird, fatty, inflammation-spewing blobs called 'coralthelial cells'—even without any bad cholesterol.
Systematic Reviews & Meta-Analyses
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Max 72Case-Control Studies
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Evidence Score
Researchers compare people who have a condition (cases) with similar people who do not (controls), looking back in time for differences in exposure. Useful but more prone to bias.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists stacked up blood vessel cells in a dish and found they turned into weird, fatty, inflammation-spewing blobs called 'coralthelial cells'—even without any bad cholesterol.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 544 / 58
Evidence Score
Researchers compare people who have a condition (cases) with similar people who do not (controls), looking back in time for differences in exposure. Useful but more prone to bias.
Publication
Authors
Zeng Y, Ouyang Z, Qiu Y, Jiang W, Jin C, Zhong J, Jin L, Qin Y, Zhao Y, Zhou X, Liu X, Fu BM
Related Content
Claims (5)
The buildup of fats and plaques in artery walls requires prior inflammation of the inner lining of blood vessels.
When human aortic endothelial cells are stacked, specific proteins involved in cellular transport and ribosome function relocate within the cell, and this is linked to higher levels of inflammatory signaling molecules being released.
In human blood vessel cells grown in layers, when the ribosomal protein RPL23 moves into the nucleolus, there is an increase in the release of specific inflammatory signaling molecules, and reducing RPL23 levels decreases this release.
When human aortic endothelial cells are grown in stacked layers in a lab, they change shape and accumulate lipid droplets at about ten times the level of cells grown in single layers, while also showing reduced levels of specific cell surface proteins associated with endothelial identity, indicating a transformation toward a foam cell-like state even without exposure to known disease-causing factors.
When human aortic endothelial cells are grown in stacked layers instead of a single layer, they produce significantly higher levels of IL-6, MCP-1, and CXCL8 messenger RNA and proteins after 11 days in culture.