Do fish oil pills calm body inflammation?
Joint Effects of One Year of Marine Omega-3 Fatty Acid Supplementation and Participant Dietary Fish Intake upon Circulating Lipid Mediators of Inflammation Resolution in a Randomized Controlled Trial
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 569 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 569 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Publication
Journal
Nutrition (Burbank, Los Angeles County, Calif.)
Year
2024
Authors
Emily G. Oakes, Iliyan Vlasakov, G. Kotler, V. Bubes, Samia Mora, Raju Tatituri, Nancy R. Cook, J. Manson, K. Costenbader
Related Content
Claims (6)
Taking a daily omega-3 supplement containing 460 mg EPA and 380 mg DHA for one year does not change the blood levels of five specific lipid molecules—Prostaglandin E2, Resolvin D2, Resolvin D5, Resolvin E1, or Leukotriene B4—in adults between 50 and 65 years old.
In adults aged 50–65, consuming more fish before starting omega-3 supplements does not change how much the supplements affect inflammation-related molecules in the blood, even though those who ate less fish showed slightly larger changes.
Taking a daily omega-3 supplement containing 460 mg EPA and 380 mg DHA for one year in adults aged 50–65 lowers specific inflammatory signaling molecules in the blood by 28–40% and increases the levels of EPA and DHA by 45–50%, reflecting a change in the body's lipid profile associated with reduced inflammation.
In adults aged 50–65 who eat little fish, taking a daily omega-3 supplement for one year raises levels of two specific lipid molecules, Resolvin D1 and Resolvin D4, by about 45% and 94% respectively. This increase is similar in people who eat a lot of fish, and the difference between the two groups is not statistically significant.
Sardines contain high amounts of omega-3 fats called EPA and DHA, which are involved in regulating inflammation and maintaining healthy heart and brain function.