Why does one thyroid pill hurt the liver and the other doesn't?

Original Title

Comparison of drug-induced liver injury risk between propylthiouracil and methimazole: A quantitative systems toxicology approach.

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Summary

Scientists used a computer model to see how two thyroid medicines, PTU and MMI, might damage the liver. They fed the computer lab data about how each drug affects liver cells.

Proposed Mechanism
PTU-induced oxidative stress leading to hepatocyte injury
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Publication

Authors

He Q, Li M, Ji P, Zheng A, Yao L, Zhu X, Shin JG, Lauschke VM, Han B, Xiang X