The Study
Recidiva y factores pronósticos tras tratamiento con antitiroideos en la enfermedad de Graves-Basedow. Estudio multicéntrico en el norte de España
This study watched a group of people with an overactive thyroid for many years and noticed that those with bigger thyroid glands were more likely to get sick again after stopping medicine. But it didn't make anyone take the medicine or change anything — it just watched what happened, so we can't say the big gland caused the sickness to come back.
Analysis score
Maximum 72 for a cohort study.
Where the score came from
Doctors gave medicine to 773 people with an overactive thyroid and watched them for up to 10 years to see who got sick again.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 539 / 100
Quality score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Key takeaways
Summary
Based on the study abstract and findings.
- 1Yes — nearly 8 out of 10 people needed another treatment like surgery or radioactive iodine because the medicine didn't cure them permanently.
- 243% came back after 1 year, 60% after 3 years, 68% after 5 years, and 79% after 10 years.
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Revista Clinica Espanola
Year
2000
Authors
E. M. Torre, E. A. Apiñániz, J. Layana, N. Gallego, A. Artal, F. Díaz-Cadórniga, J. S. Sandi, J. A. V. García
Related Content
Claims (2)
Patients with Graves' disease who stop anti-thyroid drugs before 18 months of treatment are more likely to experience a return of the disease than those who complete at least 18 months of therapy.
Patients with Graves' disease who stop anti-thyroid drugs before 18 months of treatment are more likely to experience a return of the disease. Sustained remission is uncommon without at least 18 months of continuous therapy.
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.