How yeast make an important molecule in a new way
Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Nicotinamide riboside is an unanticipated NAD+ precursor in yeast.
The abstract states that the accepted view was that all eukaryotic NAD+ biosynthesis flows through nicotinic acid mononucleotide. Finding that nicotinamide riboside can bypass this central step contradicts a foundational assumption in the field.
Practical Takeaways
Consider the potential of alternative NAD+ precursors like nicotinamide riboside in supporting cellular health, especially in the context of aging and metabolism.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Nicotinamide riboside is an unanticipated NAD+ precursor in yeast.
The abstract states that the accepted view was that all eukaryotic NAD+ biosynthesis flows through nicotinic acid mononucleotide. Finding that nicotinamide riboside can bypass this central step contradicts a foundational assumption in the field.
Practical Takeaways
Consider the potential of alternative NAD+ precursors like nicotinamide riboside in supporting cellular health, especially in the context of aging and metabolism.
Publication
Journal
Cell
Year
2004
Authors
P. Bieganowski, C. Brenner
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Claims (2)
In yeast, a substance called nicotinamide riboside can be used to make an important molecule called NAD+, and it does so through a different route than the one scientists used to think was the only way.
Your body can make an important molecule called NAD+ in more than one way — not just from one specific building block, but also from others like nicotinamide riboside.