Can a natural compound help mom's milk stay safe during infection?
Phytic Acid Maintains the Integrity of the Blood-Milk Barrier by Regulating Inflammatory Response and Intestinal Flora Structure.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
When a mouse's breast gets inflamed from infection, a substance called phytic acid helps protect the barrier that keeps milk clean and reduces swelling.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 56 / 72
Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
When a mouse's breast gets inflamed from infection, a substance called phytic acid helps protect the barrier that keeps milk clean and reduces swelling.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 56 / 72
Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Publication
Authors
Ran X, Liu J, Fu S, He F, Li K, Hu G, Guo W
Related Content
Claims (6)
Phytic acid, a compound found in plants, plays a role in biological processes that support the function and condition of the gastrointestinal tract.
Phytic acid, a compound found in plants, has been observed to reduce tissue damage and lower levels of specific inflammatory molecules in mouse mammary tissue and cells when exposed to a bacterial toxin.
In mice, phytic acid helps maintain the barrier between blood and milk in the mammary gland during inflammation by increasing the levels of proteins that seal the gaps between cells.
In mice with mammary inflammation, phytic acid changes the types and amounts of bacteria present in the intestines, as measured by genetic sequencing of microbial DNA.
Phytic acid reduces activity in a specific cellular signaling pathway known as AKT/NF-κB in mammary cells, which is associated with decreased inflammation.