Why do some people get fatter than others when they eat too much?

Original Title

PREDICTORS OF BODY COMPOSITION AND BODY ENERGY CHANGES IN RESPONSE TO CHRONIC OVERFEEDING

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Summary

Scientists fed 24 healthy young men a lot of extra food for 100 days and saw that some gained more fat than others—even though they all ate the same amount.

Proposed Mechanism
Muscle Oxidative Capacity Limits Fat Accretion
Supported by evidence
Cardiorespiratory Fitness Enhances Energy Expenditure and Reduces Fat Gain
Supported by evidence
Postprandial Thermogenesis Limits Fat Accumulation
Supported by evidence
Androgen Precursors Promote Energy Expenditure and Reduce Fat Gain
Suggested
Thyroid Responsiveness Modulates Energy Partitioning Toward Lean Mass
Suggested
Adipocyte Hypertrophy Predicts Enhanced Fat Storage Capacity
Supported by evidence
Leptin Resistance or High Baseline Leptin Promotes Fat Storage
Suggested

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Quality Analysis
Methodology
38%
Lower QualityOverall Score
Randomized Controlled TrialMedicine

Systematic Reviews & Meta-Analyses

Max 100

Randomized Controlled Trials

Max 90

Cohort Studies

Max 72

Case-Control Studies

Max 58

Cross-Sectional Studies

Max 44

Case Reports & Case Series

Max 30

Expert Opinion & Narrative Reviews

Max 5
StrongerWeaker
Randomized Controlled Trials
Level 1b
38

38 / 90

Evidence Score

Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.

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