Can mice absorb tiny HA pills through their tummy?
Steady state plasma and tissue distribution of low molecular weight hyaluronic acid after oral administration in mice
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
HA was detected in the eyes and vagina after oral administration.
It’s widely believed that oral HA is too large or fragile to survive digestion or reach systemic tissues—especially sensitive areas like eyes and reproductive organs.
Practical Takeaways
If you take oral HA supplements, look for products with very low molecular weight (under 10 kDa) and high doses—though human equivalents are unknown.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
HA was detected in the eyes and vagina after oral administration.
It’s widely believed that oral HA is too large or fragile to survive digestion or reach systemic tissues—especially sensitive areas like eyes and reproductive organs.
Practical Takeaways
If you take oral HA supplements, look for products with very low molecular weight (under 10 kDa) and high doses—though human equivalents are unknown.
Publication
Journal
Natural Product Research
Year
2023
Authors
Federica Mannino, N. Irrera, Giovanni Pallio, A. Bitto
Related Content
Claims (4)
If you give female mice a special kind of hyaluronic acid pill every day for a week, their bodies end up with more of this substance in their blood and several organs like their skin, eyes, and bladder.
If you give tiny mice a special kind of jelly-like substance through their mouth for a week, it shows up in places like their eyes and bladder—even though they didn’t swallow it there—meaning it traveled through their body.
Giving mice a specific type of hyaluronic acid pill every day for a week doesn't make more of it show up in their blood or body tissues compared to mice that just got water.
When you swallow hyaluronic acid, only about 2% of it actually gets into your bloodstream, no matter how big or small the molecules are, because your gut breaks it down too much and doesn’t let much through.