Do diabetes weight-loss drugs also lower blood pressure and save lives?
Effect of Incretin-Based Therapies on Blood Pressure: A Systematic Review and Meta-Analysis.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
These drugs, meant for weight loss in people with overweight or obesity, also gently lower blood pressure and may help people live longer without increasing dangerous side effects.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 547 / 100
Evidence Score
The highest quality evidence. These studies systematically search, appraise, and synthesize results from multiple individual studies, providing the most reliable summary of current knowledge.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
These drugs, meant for weight loss in people with overweight or obesity, also gently lower blood pressure and may help people live longer without increasing dangerous side effects.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 547 / 100
Evidence Score
The highest quality evidence. These studies systematically search, appraise, and synthesize results from multiple individual studies, providing the most reliable summary of current knowledge.
Publication
Authors
Basile C, Merolla A, Mancusi C, De Luca C, Fucile I, Canonico ME, Giugliano G, Orso F, Morisco C, Esposito G
Related Content
Claims (6)
Medications that activate multiple related hormone receptors lower blood pressure more than those activating only one receptor in adults with overweight or obesity, with measurable differences in systolic and diastolic readings.
Medications called incretin-based therapies, such as GLP-1 receptor agonists, lower systolic blood pressure by about 3.4 mmHg and diastolic blood pressure by about 0.9 mmHg in adults who have overweight or obesity.
Adults with overweight or obesity who take incretin-based therapies have a lower risk of dying from any cause compared to those who do not, based on combined data from multiple studies.
In adults with overweight or obesity who are taking incretin-based therapies, those who lose more weight tend to have larger decreases in both their systolic and diastolic blood pressure.
Medications that target incretin hormones do not raise the likelihood of low blood sugar or pancreatitis in adults who are overweight or obese.