Why your gut might still be leaky even when IBD feels under control
Intestinal Permeability In Vivo in Patients With Inflammatory Bowel Disease: Comparison of Active Disease and Remission.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Even when people with IBD feel better and their intestines look normal on scans, their gut lining is still more 'leaky' than healthy people’s.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 544 / 44
Evidence Score
A snapshot of a population at a single point in time. Can identify correlations and prevalence, but cannot determine the direction of cause and effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Even when people with IBD feel better and their intestines look normal on scans, their gut lining is still more 'leaky' than healthy people’s.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 544 / 44
Evidence Score
A snapshot of a population at a single point in time. Can identify correlations and prevalence, but cannot determine the direction of cause and effect.
Publication
Authors
Dunleavy KA, Rypstra CR, Busciglio I, Eckert D, Ryks M, Omerdic E, Chedid VG, Raffals LE, Camilleri M
Related Content
Claims (6)
People with inflammatory bowel disease often have a more permeable intestinal barrier, and this same condition is commonly observed in other chronic diseases.
In people with inflammatory bowel disease, the level of intestinal permeability measured by a specific urine test is similar whether their disease is active or in remission, suggesting that the barrier function of the gut remains altered regardless of symptom status.
People with inflammatory bowel disease show increased leakage of a sugar molecule called 13C-mannitol through the small intestine during both active flare-ups and periods of remission, compared to healthy individuals, while another sugar, lactulose, shows no difference in excretion during the same time window.
Measuring the ratio of lactulose to mannitol in urine does not reliably detect changes in intestinal permeability in people with inflammatory bowel disease compared to healthy individuals or between disease states. However, the individual amounts of 13C-mannitol and lactulose excreted in urine are higher in people with inflammatory bowel disease.
In people with inflammatory bowel disease, the level of gut barrier leakage does not consistently match the severity of visible inflammation in the intestine as seen during endoscopy.